Cross-Linked Hyaluronic Acid for Regenerative Dentistry
hyaDENT BG is developed and distributed by Regedent Switzerland, founded by former Straumann and Geistlich professionals.
Discover a new approach to soft tissue management with cross-linked hyaluronic acid and learn how you can improve healing dynamics, wound stability, and regenerative outcomes for your patients in periodontal and peri-implant therapy. Achieve predictable, standardized outcomes whenever you need them with hyaDENT BG.
Biological Basis
Hyaluronic Acid in Dentistry
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan and a fundamental component of the extracellular matrix. Due to its high biocompatibility and multifunctional biological properties, HA has gained increasing relevance in modern dentistry, particularly in periodontal and regenerative procedures.
Within oral tissues—including gingiva, periodontal ligament, alveolar bone, and peri-implant soft tissues—HA is not merely a structural molecule, but an active biological regulator. It plays a critical role in cellular adhesion, migration, and proliferation, thereby directly influencing wound healing, tissue repair, and regenerative processes.
Although HA has historically been underestimated in dental practice and often associated mainly with hydration or cosmetic applications, this perception is outdated. In reality, HA actively participates in inflammation control, fibroblast activity, epithelial migration, angiogenesis, and extracellular matrix organization.
These biological effects are highly relevant in dentistry, where predictable healing depends on a stable wound environment, controlled inflammation, and coordinated soft and hard tissue regeneration.
Modern HA-based biomaterials with improved stability and prolonged residence time have helped redefine HA as a bioactive therapeutic component capable of supporting more predictable periodontal and peri-implant tissue regeneration.
HA-based biomaterials support inflammation control, angiogenesis, matrix remodeling, and tissue regeneration during wound healing.
Clinical Relevance
Clinical Relevance in Dentistry
Hyaluronic acid (HA) contributes to wound stabilization, angiogenesis, extracellular matrix organization, and soft tissue regeneration while supporting a controlled inflammatory response. Through its hygroscopic and viscoelastic properties, HA helps maintain a hydrated and biologically stable wound environment during the different phases of healing.
In periodontal and peri-implant therapy, these biological effects are particularly relevant due to the chronic inflammatory nature of tissue destruction and the complexity of regenerative healing. HA has been shown to support fibroblast proliferation, epithelial migration, neovascularization, and early tissue maturation while contributing to improved wound stability and healing dynamics.
Beyond its biological activity, HA also offers important clinical handling advantages. Its cohesive and viscoelastic characteristics allow precise application and improve the adaptation and stabilization of grafting materials within the surgical site.
Periodontal Pocket Management
hyaDENT BG may support the treatment of persistent periodontal pockets by stabilizing the blood clot and supporting regenerative wound healing. Clinical experience and emerging evidence suggest improvements in probing pocket depth (PPD) reduction and clinical attachment gain when cross-linked hyaluronic acid is used adjunctively following subgingival instrumentation.
Gingivitis & Periodontitis
Due to its anti-inflammatory, bacteriostatic, and wound-modulating properties, hyaDENT BG may support the management of inflammatory periodontal conditions. Hyaluronic acid has been shown to influence fibroblast activity, epithelial migration, and soft tissue healing while contributing to inflammation control
Peri-Implant Mucositis
In peri-implant soft tissue inflammation, hyaDENT BG may help stabilize the peri-implant environment and support mucosal healing. Studies evaluating hyaluronic acid in peri-implant therapy report beneficial effects on inflammation control, wound healing, and clinical peri-implant parameters when used as an adjunctive treatmen
Post-Surgical Wound Healing?
The prolonged residence time and viscoelastic properties of cross-linked hyaluronic acid help maintain a hydrated and protected wound environment. hyaDENT BG may support angiogenesis, clot stabilization, soft tissue maturation, and reduction of postoperative discomfort during the healing phase.
Soft Tissue Management
In mucogingival and periodontal plastic procedures, hyaDENT BG may support soft tissue quality, vascularization, and wound stability. Its cohesive gel consistency also facilitates precise application and adaptation within delicate soft tissue surgical site
Guided Bone Regeneration
When combined with particulate grafting materials, hyaDENT BG may improve graft cohesion, stabilization, and handling characteristics while supporting regenerative healing. Cross-linked hyaluronic acid has been associated with enhanced soft and hard tissue regenerative dynamics in guided bone regeneration procedures.
Modern HA-based biomaterials are therefore increasingly used as adjunctive therapeutic components in regenerative and minimally invasive procedures, particularly in situations where soft tissue quality, wound stability, and predictable healing outcomes are critical.
Hyaluronic acid supports regenerative dentistry through wound stabilization, soft tissue healing, inflammation control, and improved regenerative tissue dynamics.
Tunnel Technique · Root Coverage
Minimally Invasive Recession Treatment
The tunnel technique is a minimally invasive approach for root coverage that preserves papillary integrity and vascular supply while minimizing surgical trauma. In combination with connective tissue grafting and hyaDENT BG application, the procedure supports wound stability, soft tissue healing, and predictable esthetic outcomes.
Prof. Anton Sculean
Professor and Chairman, Department of Periodontology University of Bern, Switzerland
Internationally recognized expert in periodontal regeneration, minimally invasive periodontal therapy, and wound healing. Author of more than 600 scientific publications and Editor-in-Chief of Periodontology 2000.
1. Baseline
Evaluation
2. Tunnel
Preparation
3. Connective TissueGraft (CTG)
Graft (CTG)
4. Application of
hyaDENT BG
5. Six-Month
Result
Designed for Efficient Regenerative Workflows
hyaDENT BG is designed to simplify regenerative procedures in daily periodontal and peri-implant practice through easy and efficient application. The cohesive cross-linked gel can be applied directly to the surgical site and integrates seamlessly into existing regenerative workflows without adding procedural complexity.
Its handling characteristics support efficient graft adaptation, wound stabilization, and controlled application during both soft tissue and bone regenerative procedures. By simplifying workflow steps and reducing technique sensitivity, hyaDENT BG helps clinicians save chairtime while supporting predictable healing dynamics and consistent clinical performance.
Whether used in periodontal defects, peri-implant therapy, extraction sockets, or sticky bone protocols, hyaDENT BG allows clinicians to integrate biologically active regenerative support into daily practice with minimal effort and maximum procedural simplicity.
Practical Advantages
- Fast and easy application
- Simplified regenerative workflows
- Reduced technique sensitivity
- Improved graft stabilization
- Efficient integration into daily practice
- Support for minimally invasive procedures
- Reduced postoperative discomfort
- Predictable regenerative outcomes
The simplified application concept allows clinicians to incorporate biologically active regenerative support into surgical workflows without additional preparation complexity. hyaDENT BG can be applied directly chairside and adapts efficiently to different regenerative protocols, making it particularly suitable for daily clinical use in modern minimally invasive dentistry.
Practical chairside workflow for fast and efficient sticky bone preparation with hyaDENT BG.
8-Year Follow-Up · Infrabony Defect
Regenerative Treatment of an Infrabony Defect
This clinical case shows the regenerative treatment of a deep periodontal defect with an initial probing depth of 10 mm. hyaDENT BG was mixed with bone filler to support clot stability, wound healing, and periodontal regeneration, resulting in a probing depth reduction to 2–3 mm after 8 years.
Prof. Andrea Pilloni
Professor and Chairman, Section of Periodontology Sapienza University of Rome, Italy
Leading authority in regenerative periodontology and periodontal plastic surgery, with extensive expertise in soft tissue healing and biomaterial-based therapies. Widely published researcher and sought-after international speaker in the field of periodontology.
1. Initial Situation:PPD of 10 mm
2. Baseline radiograph showing vertical bone loss
3. Defect filled with a mixture of HyaDENT BG and a bone filler.
4. Situation 72h post-OP shows accelerated healing.
5. AFTER 8 YEARS Significant reduction of probing depth to 2–3 mm
Therapeutic Implications
Conclusion
Hyaluronic acid has evolved from a traditionally supportive biomaterial into a biologically active component of contemporary periodontal and peri-implant therapy. Advances in cross-linked Hyaluronic Acid technology now enable prolonged bioactivity, enhanced wound stability, and more predictable regenerative healing outcomes.
By modulating the healing microenvironment, supporting angiogenesis, and promoting organized tissue regeneration, hyaDENT BG contributes to improved soft tissue healing, regenerative stability, and clinical predictability across minimally invasive and regenerative procedures.
As regenerative dentistry continues to shift toward biologically driven therapeutic concepts, advanced hyaluronic acid formulations should no longer be regarded merely as adjunctive materials, but as active components of modern periodontal and implant therapy.
hyaDENT BG
Cross-Linked Hyaluronic Acid for Regenerative Dentistry
Immediate delivery from Turkey stock — delivery time 1–2 business days.
hyaDENT BG is Used by Leading Regenerative Clinicians
Dr. Olcay Bakar
Marmara University
Prof. Belir Atalay
